Abstract
A series of 8-azabicyclo[3.2.1]octane amine hNK1 antagonists has been investigated and structure-activity relationships of the benzylamine and 6-exo substituents described. Acidic substituents at C6 give a series of high affinity compounds for hNK1 with selectivity over the hERG channel.
MeSH terms
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Aza Compounds / chemical synthesis*
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Aza Compounds / chemistry
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Bridged Bicyclo Compounds, Heterocyclic / chemical synthesis*
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Bridged Bicyclo Compounds, Heterocyclic / chemistry
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Humans
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Molecular Conformation
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Neurokinin-1 Receptor Antagonists*
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Stereoisomerism
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Structure-Activity Relationship
Substances
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8-azabicyclo(3.2.1)octane benzylamine
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Aza Compounds
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Bridged Bicyclo Compounds, Heterocyclic
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Neurokinin-1 Receptor Antagonists